Costantina Maisto

Extensive Experience in Quality Control of PET Radiopharmaceuticals: Proven expertise in the quality control of PET radiopharmaceuticals such as [18F]FDG, [18F]Choline, [18F]F-PSMA-1007, [68Ga]DOTATOC, and [68Ga]Ga-PSMA-11, according to GMP in Nuclear Medicine.

• In-depth Knowledge of NBP/GLP and GCP Standards: Skilled in adhering to and implementing Good Laboratory Practices (GLP) and Good Clinical Practices (GCP) to ensure compliance and excellence.
• Development of New PET Radiotracers: Initial hands-on experience in quality control of emerging radiotracers, including [18F]AlF-FAPI-74 and [68Ga]Ga-FAPI-46.
• Chromatographic Method Validation: Proficient in validating chromatographic methods to ensure analytical precision and reliability.
• Documentation Management:
  Expert in creating, reviewing, and managing production and quality control SOPs, Batch Records, and Instrumentation Log Books.

Technical Expertise:

• Radio-HPLC Systems; Thin-Layer Radio-Chromatography, Pyrogenicity Assessment, Radionuclidic Purity Evaluation, Chemical Impurity Analysis.

Expertise in the Preparation and Dispensing of Radiopharmaceuticals:

• Skilled in preparing diagnostic radiopharmaceuticals ([18F]FDG, [18F]F-PSMA-1007, [68Ga]DOTATOC) using semi-automated synthesis modules according to Pharmacopoeia requirements.
• Proficient in dispensing radiopharmaceuticals with automated systems.

Research and Development Proficiency:

• Extensive experience in Ga-68 microlabeling of peptides for research applications and monodispersed polymeric compounds.
• Demonstrated expertise in conducting in vitro and in vivo testing using Micro-PET/CT systems to evaluate the pharmacokinetics and biodistribution of innovative compounds.

Proficiency in Peptide Synthesis and Characterization:

• Solid-Phase Peptide Synthesis: Skilled in batch synthesis of peptides and peptidomimetics using solid-phase techniques.
• Chromatographic Techniques: Experienced in thin-layer chromatography (TLC) and column chromatography for analyzing and purifying compounds.
• Peptide Characterization: Knowledgeable in applying diverse methodologies to characterize peptide structures and properties.
• Preparative HPLC Purification: Expertise in purifying peptides using preparative high-performance liquid chromatography (HPLC).
• Lyophilization: Competent in the lyophilization of target products to ensure stability and usability.