Nicolò Santi

◼ Medicinal chemist with a strong background in organic, medicinal and biological chemistry. Excellent ability to manage cross-functional discovery team in close collaboration with international scientists from the chemistry, biological, and pharmaceutical sciences department leading to successful generation of several multidisciplinary international projects.
◼ Excellent team player and strong builder of prolific collaborations in different aspects of basic and applied research to long-lasting research projects, with 8 peer-reviewed scientific publications.
◼ Creative and self-motivated individual with easy-integration in a multicultural environment with unique combination of detail-oriented mindset, driven personality, analytical skills and proven ability to meet tight deadlines by working in a fast-paced work environment.

MSCA Postdoctoral Fellowships 2021, Awarded (Score: 94.2/100) for the project proposal BLISS (Beta-Lactamase Inhibitors Synthesised through in Situ click chemistry). Total contribution received: 188 590.08 €

• Synthesis of a Novel Boronic Acid Transition State Inhibitor, MB076, J. Med. Chem., 2023
• The role of streptavidin and its variants in catalysis by biotinylated secondary amines, Org. Biomol. Chem., 2021
• Identifying and validating the presence of Guanine-Quadruplexes (G4) within the blood fluke parasite Schistosoma mansoni, PLOS Negl. Trop. Dis., 2021
• Transfer hydrogenations catalyzed by streptavidin-hosted secondary amine organocatalysts, Chem. Comm., 2021
• Streptavidin-hosted organocatalytic aldol addition, Molecules, 2020
• Enabling protein-hosted organocatalytic transformations, RSC Advances, 2020
• Comparative biological evaluation and G-quadruplex interaction studies of two new families of organometallic gold(I) complexes, J. Inorg. Biochem., 2020
• Reactions of biologically inspired hydride sources with B(C6F5)3, Philos. Trans. A Math. Phys. Eng. Sci., 2017

Communication skills

o 6th International Caparica Conference on Antibiotic Resistance (IC2AR 2024), Caparica, Portugalm 8-12 September 2024 (TALK): BLISS: Beta-Lactamase Inhibitors Synthesised through in Situ click chemistry.

o Gordon Research Conference on New Antibacterial Discovery and Development, Ventura, United States of America, 17-22 March 2024(POSTER):BLISS: Beta-Lactamase Inhibitors Synthesised through in Situ click chemistry.

o 7thInterdisciplinary Course on Antibiotics and Resistance (ICARe), Annecy, France, 7-15 October 2024 (POSTER): BLISS: Beta-Lactamase Inhibitors Synthesised through in Situ click chemistry.

o 14thBeta-lactamase Meeting, L’Aquila, Italy, 2-5 June 2023 (POSTER): BLISS: Beta-Lactamase Inhibitors Synthesised through in Situ click chemistry.

o 5thApproaches for Identification of Antiviral Agents Summer School (IAAASS), Cagliari (Online), 22-24 September 2021 (TALK): Identification of Novel Non-Nucleoside Inhibitors of Dengue Virus NS5 RNA-Dependent RNA Polymerase.

o 18thCardiff Chemistry Conference (CCC), Cardiff, United Kingdom, 14-15 May 2019 (TALK): Artificial Enzyme Design: Enabling iminium catalysis within a protein scaffold.

o RSC Chemical Biology and Bioorganic Group Postgraduate Symposium, Southampton, United Kingdom, 26 April 2019 (POSTER): Artificial Enzyme Design: Enabling iminium catalysis within a protein scaffold.

Courses and Training

v 7th Interdisciplinary Course on ICAre Antibiotics and Resistances, Les Pensières Center for Global Health, Veryer-du-Lac, France, 7-15 October 2023 (Course).

v Visiting Post-Doc at Prof. Mariagrazia Perilli laboratory, Department of Applied Clinical Sciences and Biotechnology, Università degli studi dell’Aquila (UNIVAQ), L’Aquila, Italy, December 2023 (Training).

v Visiting Post-Doc at Prof. Robert Bonomo laboratory, Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University (CWRU), Cleveland, USA, July-August 2024 (Training).