

Expert in molecular and cellular biology with advanced skills in statistical analysis and imaging. Ability to work in multicultural teams and manage complex projects. Responsible for optimizing new protocols and training new students and technicians.
Search: AU-ID("Zecchini, Silvia" 57192331106)
1) Catalani, E., Zecchini, S., Giovarelli, M., Cherubini, A., Del Quondam, S., Brunetti, K., Silvestri, F.,
Roux-Biejat, P., Napoli, A., Casati, S.R., Ceci, M., Romano, N., Bongiorni, S., Prantera, G., Clementi,
E., Perrotta, C., De Palma, C., Cervia, D.
RACK1 is evolutionary conserved in satellite stem cell activation and adult skeletal muscle
regeneration
(2022) Cell Death Discovery, 8 (1), art. no. 459, .
1) https://www.scopus.com/inward/record.uri?eid=2-s2.0-85142240822&doi=10.1038%2fs41420-022-01250-8&partnerID=40&md5=DOI: 10.1038/s41420-022-01250-8
Document Type: Article
Publication Stage: Final
Access Type: Open Access
Source: Scopus
2) Filippone, M.G., Freddi, S., Zecchini, S., Restelli, S., Colaluca, I.N., Bertalot, G., Pece, S., Tosoni, D.,
Di Fiore, P.P.
Aberrant phosphorylation inactivates Numb in breast cancer causing expansion of the stem cell pool
(2022) Journal of Cell Biology, 221 (12), art. no. e202112001, .
2) https://www.scopus.com/inward/record.uri?eid=2-s2.0-85139377616&doi=10.1083%2fjcb.202112001&partnerID=40&md5=891b6d6719391f01aae3d205bb741f63
DOI: 10.1083/jcb.202112001
Document Type: Article
Publication Stage: Final
Source: Scopus
3) Giovarelli, M., Arnaboldi, F., Zecchini, S., Cornaghi, L.B., Nava, A., Sommariva, M., Clementi, E.G.I.,
Gagliano, N.
Characterisation of Progressive Skeletal Muscle Fibrosis in the Mdx Mouse Model of Duchenne
Muscular Dystrophy: An In Vivo and In Vitro Study
(2022) International Journal of Molecular Sciences, 23 (15), art. no. 8735, . Cited 3 times.
3) https://www.scopus.com/inward/record.uri?eid=2-s2.0-85137097356&doi=10.3390%2fijms23158735&partnerID=40&md5=d7a198b3e8dda98b2be9f3d58804e4eb
DOI: 10.3390/ijms23158735
Document Type: Article
Publication Stage: Final
Access Type: Open Access
Source: Scopus
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4) Limanaqi, F., Zecchini, S., Dino, B., Strizzi, S., Cappelletti, G., Utyro, O., Vanetti, C., Garziano, M.,
Saulle, I., Clerici, M., Biasin, M.
Dopamine Reduces SARS-CoV-2 Replication In Vitro through Downregulation of D2 Receptors and
Upregulation of Type-I Interferons
(2022) Cells, 11 (10), art. no. 1691, . Cited 1 time.
4) https://www.scopus.com/inward/record.uri?eid=2-s2.0-85130241780&doi=10.3390%2fcells11101691&partnerID=40&md5=cc2d1fa8032aa480bb9f6de953848d35
DOI: 10.3390/cells11101691
Document Type: Article
Publication Stage: Final
Access Type: Open Access
Source: Scopus
5) Catalani, E., Giovarelli, M., Zecchini, S., Perrotta, C., Cervia, D.
Oxidative stress and autophagy as key targets in melanoma cell fate
(2021) Cancers, 13 (22), art. no. 5791, . Cited 6 times.
5) https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119683167&doi=10.3390%2fcancers13225791&partnerID=40&md5=8374b2c123885cecefdd25943e9ee0d5
DOI: 10.3390/cancers13225791
Document Type: Article
Publication Stage: Final
Access Type: Open Access
Source: Scopus
6) Roux-Biejat, P., Coazzoli, M., Marrazzo, P., Zecchini, S., Di Renzo, I., Prata, C., Napoli, A.,
Moscheni, C., Giovarelli, M., Barbalace, M.C., Catalani, E., Bassi, M.T., De Palma, C., Cervia, D.,
Malaguti, M., Hrelia, S., Clementi, E., Perrotta, C.
Acid sphingomyelinase controls early phases of skeletal muscle regeneration by shaping the
macrophage phenotype
(2021) Cells, 10 (11), art. no. 3028, . Cited 2 times.
6) https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118473633&doi=10.3390%2fcells10113028&partnerID=40&md5=6b7a96f2e64849cc276e705abf1a305b
DOI: 10.3390/cells10113028
Document Type: Article
Publication Stage: Final
Access Type: Open Access
Source: Scopus
7) Giovarelli, M., Zecchini, S., Catarinella, G., Moscheni, C., Sartori, P., Barbieri, C., Roux-Biejat, P.,
Napoli, A., Vantaggiato, C., Cervia, D., Perrotta, C., Clementi, E., Latella, L., De Palma, C.
Givinostat as metabolic enhancer reverting mitochondrial biogenesis deficit in Duchenne Muscular
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Dystrophy
(2021) Pharmacological Research, 170, art. no. 105751, . Cited 7 times.
7) https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108986148&doi=10.1016%2fj.phrs.2021.105751&partnerID=40&md5=DOI: 10.1016/j.phrs.2021.105751
Document Type: Article
Publication Stage: Final
Source: Scopus
8) Catalani, E., Bongiorni, S., Taddei, A.R., Mezzetti, M., Silvestri, F., Coazzoli, M., Zecchini, S.,
Giovarelli, M., Perrotta, C., De Palma, C., Clementi, E., Ceci, M., Prantera, G., Cervia, D.
Defects of full-length dystrophin trigger retinal neuron damage and synapse alterations by disrupting
functional autophagy
(2021) Cellular and Molecular Life Sciences, 78 (4), pp. 1615-1636. Cited 11 times.
8) https://www.scopus.com/inward/record.uri?eid=2-s2.0-85088939421&doi=10.1007%2fs00018-020-03598-5&partnerID=40&md5=DOI: 10.1007/s00018-020-03598-5
Document Type: Article
Publication Stage: Final
Access Type: Open Access
Source: Scopus
9) Giovarelli, M., Zecchini, S., Martini, E., Garrè, M., Barozzi, S., Ripolone, M., Napoli, L., Coazzoli, M.,
Vantaggiato, C., Roux-Biejat, P., Cervia, D., Moscheni, C., Perrotta, C., Parazzoli, D., Clementi, E.,
De Palma, C.
Drp1 overexpression induces desmin disassembling and drives kinesin-1 activation promoting
mitochondrial trafficking in skeletal muscle
(2020) Cell Death and Differentiation, 27 (8), pp. 2383-2401. Cited 17 times.
9) https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079464368&doi=10.1038%2fs41418-020-0510-7&partnerID=40&md5=DOI: 10.1038/s41418-020-0510-7
Document Type: Article
Publication Stage: Final
Access Type: Open Access
Source: Scopus
10) Coazzoli, M., Napoli, A., Roux-Biejat, P., Palma, C., Moscheni, C., Catalani, E., Zecchini, S., Conte,
V., Giovarelli, M., Caccia, S., Procacci, P., Cervia, D., Clementi, E., Perrotta, C.
Acid Sphingomyelinase Downregulation Enhances Mitochondrial Fusion and Promotes Oxidative
Metabolism in a Mouse Model of Melanoma
(2020) Cells, 9 (4), . Cited 4 times.
10)
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102394534&doi=10.3390%2fcells9040848&partnerID=40&md5=8d6ce0eaa746f9f956a7cb0af330b526
DOI: 10.3390/cells9040848
Document Type: Article
Publication Stage: Final
Access Type: Open Access
Source: Scopus
11) Muñoz, D., Brucoli, M., Zecchini, S., Sandoval-Hernandez, A., Arboleda, G., Lopez-Vallejo, F.,
Delgado, W., Giovarelli, M., Coazzoli, M., Catalani, E., De Palma, C., Perrotta, C., Cuca, L., Clementi,
E., Cervia, D.
XIAP as a target of new small organic natural molecules inducing human cancer cell death
(2019) Cancers, 11 (9), art. no. 1336, . Cited 8 times.
11) https://www.scopus.com/inward/record.uri?eid=2-s2.0-85073331569&doi=10.3390%2fcancers11091336&partnerID=40&md5=bfdd6147011220ddd02608a0959cb14e
DOI: 10.3390/cancers11091336
Document Type: Article
Publication Stage: Final
Access Type: Open Access
Source: Scopus
12) Castiglioni, S., Romeo, V., Locatelli, L., Zocchi, M., Zecchini, S., Maier, J.A.M.
The simultaneous downregulation of TRPM7 and MagT1 in human mesenchymal stem cells in vitro:
Effects on growth and osteogenic differentiation
(2019) Biochemical and Biophysical Research Communications, 513 (1), pp. 159-165. Cited 11 times.
12) https://www.scopus.com/inward/record.uri?eid=2-s2.0-85063607389&doi=10.1016%2fj.bbrc.2019.03.178&partnerID=40&md5=23af43b55e40084fecaa51ae37cdd7bf
DOI: 10.1016/j.bbrc.2019.03.178
Document Type: Article
Publication Stage: Final
Source: Scopus
13) Zecchini, S., Giovarelli, M., Perrotta, C., Morisi, F., Touvier, T., Di Renzo, I., Moscheni, C., Bassi,
M.T., Cervia, D., Sandri, M., Clementi, E., De Palma, C.
Autophagy controls neonatal myogenesis by regulating the GH-IGF1 system through a NFE2L2- and
DDIT3-mediated mechanism
(2019) Autophagy, 15 (1), pp. 58-77. Cited 31 times.
13) https://www.scopus.com/inward/record.uri?eid=2-s2.0-85053336745&doi=10.1080%2f15548627.2018.1507439&partnerID=40&DOI: 10.1080/15548627.2018.1507439
Document Type: Article
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Publication Stage: Final
Access Type: Open Access
Source: Scopus
14) Catalani, E., Buonanno, F., Lupidi, G., Bongiorni, S., Belardi, R., Zecchini, S., Giovarelli, M., Coazzoli,
M., Palma, C.D., Perrotta, C., Clementi, E., Prantera, G., Marcantoni, E., Ortenzi, C., Fausto, A.M.,
Picchietti, S., Cervia, D.
The natural compound climacostol as a prodrug strategy based on pH activation for efficient delivery
of cytotoxic small agents
(2019) Frontiers in Chemistry, 7 (JUN), art. no. 463, . Cited 10 times.
14) https://www.scopus.com/inward/record.uri?eid=2-s2.0-85068506057&doi=10.3389%2ffchem.2019.00463&partnerID=40&md5=2daf9b78cbff5f2e1f891b720c4df362
DOI: 10.3389/fchem.2019.00463
Document Type: Article
Publication Stage: Final
Access Type: Open Access
Source: Scopus
15) Zecchini, S., Proietti Serafini, F., Catalani, E., Giovarelli, M., Coazzoli, M., Di Renzo, I., De Palma, C.,
Perrotta, C., Clementi, E., Buonanno, F., Ortenzi, C., Marcantoni, E., Taddei, A.R., Picchietti, S.,
Fausto, A.M., Cervia, D.
Dysfunctional autophagy induced by the pro-apoptotic natural compound climacostol in tumour cells
(2019) Cell Death and Disease, 10 (1), art. no. 10, . Cited 15 times.
15) https://www.scopus.com/inward/record.uri?eid=2-s2.0-85058927053&doi=10.1038%2fs41419-018-1254-x&partnerID=40&md5=DOI: 10.1038/s41419-018-1254-x
Document Type: Article
Publication Stage: Final
Access Type: Open Access
Source: Scopus
16) Perrotta, C., Cervia, D., Di Renzo, I., Moscheni, C., Bassi, M.T., Campana, L., Martelli, C., Catalani,
E., Giovarelli, M., Zecchini, S., Coazzoli, M., Capobianco, A., Ottobrini, L., Lucignani, G., Rosa, P.,
Rovere-Querini, P., De Palma, C., Clementi, E.
Nitric oxide generated by tumor-associated macrophages is responsible for cancer resistance to
cisplatin and correlated with syntaxin 4 and acid sphingomyelinase inhibition
(2018) Frontiers in Immunology, 9 (MAY), art. no. 1186, . Cited 55 times.
16) https://www.scopus.com/inward/record.uri?eid=2-s2.0-85047793659&doi=10.3389%2ffimmu.2018.01186&partnerID=40&md5=657703411ba1c3a669e42f985cb429f6
DOI: 10.3389/fimmu.2018.01186
Document Type: Article
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Publication Stage: Final
Access Type: Open Access
Source: Scopus
17) Tosoni, D., Pambianco, S., Ekalle Soppo, B., Zecchini, S., Bertalot, G., Pruneri, G., Viale, G., Di
Fiore, P.P., Pece, S.
Pre-clinical validation of a selective anti-cancer stem cell therapy for Numb-deficient human breast
cancers
(2017) EMBO Molecular Medicine, 9 (5), pp. 655-671. Cited 28 times.
17) https://www.scopus.com/inward/record.uri?eid=2-s2.0-85015147490&doi=10.15252%2femmm.201606940&partnerID=40&md5=DOI: 10.15252/emmm.201606940
Document Type: Article
Publication Stage: Final
Access Type: Open Access
Source: Scopus
18) Pambianco, S., Giovarelli, M., Perrotta, C., Zecchini, S., Cervia, D., Di Renzo, I., Moscheni, C.,
Ripolone, M., Violano, R., Moggio, M., Bassi, M.T., Puri, P.L., Latella, L., Clementi, E., De Palma, C.
Reversal of Defective Mitochondrial Biogenesis in Limb-Girdle Muscular Dystrophy 2D by
Independent Modulation of Histone and PGC-1α Acetylation
(2016) Cell Reports, 17 (11), pp. 3010-3023. Cited 25 times.
18) https://www.scopus.com/inward/record.uri?eid=2-s2.0-85004043418&doi=10.1016%2fj.celrep.2016.11.044&partnerID=40&md5=DOI: 10.1016/j.celrep.2016.11.044
Document Type: Article
Publication Stage: Final
Access Type: Open Access
Source: Scopus
19) Catalani, E., Proietti Serafini, F., Zecchini, S., Picchietti, S., Fausto, A.M., Marcantoni, E., Buonanno,
F., Ortenzi, C., Perrotta, C., Cervia, D.
Natural products from aquatic eukaryotic microorganisms for cancer therapy: Perspectives on
anti-tumour properties of ciliate bioactive molecules
(2016) Pharmacological Research, 113, pp. 409-420. Cited 35 times.
19) https://www.scopus.com/inward/record.uri?eid=2-s2.0-84988384032&doi=10.1016%2fj.phrs.2016.09.018&partnerID=40&md5=3795b9df90435100c46891bca4f2bc24
DOI: 10.1016/j.phrs.2016.09.018
Document Type: Review
Publication Stage: Final
Source: Scopus
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20) Perrotta, C., Buonanno, F., Zecchini, S., Giavazzi, A., Proietti Serafini, F., Catalani, E., Guerra, L.,
Belardinelli, M.C., Picchietti, S., Fausto, A.M., Giorgi, S., Marcantoni, E., Clementi, E., Ortenzi, C.,
Cervia, D.
Climacostol reduces tumour progression in a mouse model of melanoma via the p53-dependent
intrinsic apoptotic programme
(2016) Scientific Reports, 6, art. no. 27281, . Cited 30 times.
20) https://www.scopus.com/inward/record.uri?eid=2-s2.0-84974622919&doi=10.1038%2fsrep27281&partnerID=40&md5=904c2fa5bb7f3fa287b76c6ac38f2c7d
DOI: 10.1038/srep27281
Document Type: Article
Publication Stage: Final
Access Type: Open Access
Source: Scopus
21) Cervia, D., Assi, E., De Palma, C., Giovarelli, M., Bizzozero, L., Pambianco, S., Di Renzo, I.,
Zecchini, S., Moscheni, C., Vantaggiato, C., Procacci, P., Clementi, E., Perrotta, C.
Essential role for acid sphingomyelinase-inhibited autophagy in melanoma response to cisplatin
(2016) Oncotarget, 7 (18), pp. 24995-25009. Cited 29 times.
21) https://www.scopus.com/inward/record.uri?eid=2-s2.0-84967261194&doi=10.18632%2foncotarget.8735&partnerID=40&md5=4e5bc3b814aa4837b48507423da974e0
DOI: 10.18632/oncotarget.8735
Document Type: Article
Publication Stage: Final
Access Type: Open Access
Source: Scopus
22) Tosoni, D., Zecchini, S., Coazzoli, M., Colaluca, I., Mazzarol, G., Rubio, A., Caccia, M., Villa, E.,
Zilian, O., Di Fiore, P.P., Pece, S.
The Numb/p53 circuitry couples replicative self-renewal and tumor suppression in mammary epithelial
cells
(2015) Journal of Cell Biology, 211 (4), pp. 845-862. Cited 49 times.
22) https://www.scopus.com/inward/record.uri?eid=2-s2.0-84970946060&doi=10.1083%2fjcb.201505037&partnerID=40&md5=d60a3216438b2141852c287676f38b04
DOI: 10.1083/jcb.201505037
Document Type: Article
Publication Stage: Final
Access Type: Open Access
Source: Scopus
23) Zecchini, S., Bombardelli, L., Decio, A., Bianchi, M., Mazzarol, G., Sanguineti, F., Aletti, G.,
Maddaluno, L., Berezin, V., Bock, E., Casadio, C., Viale, G., Colombo, N., Giavazzi, R., Cavallaro, U.
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The adhesion molecule NCAM promotes ovarian cancer progression via FGFR signalling
(2011) EMBO Molecular Medicine, 3 (8), pp. 480-494. Cited 56 times.
23) https://www.scopus.com/inward/record.uri?eid=2-s2.0-79960965109&doi=10.1002%2femmm.201100152&partnerID=40&md5=96a45de40dc34e7ebeb9774c45878d00
DOI: 10.1002/emmm.201100152
Document Type: Article
Publication Stage: Final
Access Type: Open Access
Source: Scopus
24) Zecchini, S., Cavallaro, U.
Neural Cell adhesion molecule in cancer: Expression and mechanisms
(2010) Advances in Experimental Medicine and Biology, 663, pp. 319-333. Cited 30 times.
24) https://www.scopus.com/inward/record.uri?eid=2-s2.0-77949907296&doi=10.1007%2f978-1-4419-1170-4_20&partnerID=40&md5=DOI: 10.1007/978-1-4419-1170-4_20
Document Type: Article
Publication Stage: Final
Source: Scopus
25) Zecchini, S., Bianchi, M., Colombo, N., Fasani, R., Goisis, G., Casadio, C., Viale, G., Liu, J., Herlyn,
M., Godwin, A.K., Nuciforo, P.G., Cavallaro, U.
The differential role of L1 in ovarian carcinoma and normal ovarian surface epithelium
(2008) Cancer Research, 68 (4), pp. 1110-1118. Cited 68 times.
25) https://www.scopus.com/inward/record.uri?eid=2-s2.0-39449113026&doi=10.1158%2f0008-5472.CAN-07-2897&partnerID=40&DOI: 10.1158/0008-5472.CAN-07-2897
Document Type: Article
Publication Stage: Final
Access Type: Open Access
Source: Scopus
26) Corradi, A., Croci, L., Broccoli, V., Zecchini, S., Previtali, S., Wurst, W., Amadio, S., Maggi, R.,
Quattrini, A., Consalez, G.G.
Hypogonadotropic hypogonadism and peripheral neuropathy in Ebf2-null mice
(2003) Development, 130 (2), pp. 401-410. Cited 83 times.
26) https://www.scopus.com/inward/record.uri?eid=2-s2.0-0037265734&doi=10.1242%2fdev.00215&partnerID=40&md5=0d759ff3463717073554b54d0941c90e
DOI: 10.1242/dev.00215
Document Type: Review
Publication Stage: Final
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Source: Scopus
Certifications held:
• First Aid Training Course for Designated Personnel (Groups B-C) – 12 hours, June 2025
Regulatory references: Legislative Decree 81/2008 and Ministerial Decree 388/2003
• High-Risk Worker Safety Training – Health and Safety at Work – 12 hours, April 2025
Regulatory references: Article 37 of Legislative Decree 81/2008 and the State-Regions Agreement (21 Dec 2011, Rep. Acts No. 221/CSR)
• SINTESY.Eagle.trace INVENTORY® Software Training used in Biobanks – 11 February 2025